TWIST 2 ( twist family bHLH transcription factor 2 )
نویسندگان
چکیده
Review on TWIST2, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
منابع مشابه
An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors.
Basic helix-loop-helix (bHLH) transcription factors recognize the canonical E-box (CANNTG) to regulate gene transcription; however, given the prevalence of E-boxes in a genome, it has been puzzling how individual bHLH proteins selectively recognize E-box sequences on their targets. TWIST is a bHLH transcription factor that promotes epithelial-mesenchymal transition (EMT) during development and ...
متن کاملTwist-2 Controls Myeloid Lineage Development and Function
Basic helix-loop-helix (bHLH) transcription factors play critical roles in lymphoid and erythroid development; however, little is known about their role in myeloid lineage development. In this study, we identify the bHLH transcription factor Twist-2 as a key negative regulator of myeloid lineage development, as manifested by marked increases in mature myeloid populations of macrophages, neutrop...
متن کاملAtlas of Genetics and Cytogenetics in Oncology and Haematology
The TWIST proteins are embryonic transcription factors that play key roles in embryonic development. While they remain largely undetectable in healthy adult tissues, both TWIST1 and TWIST2 genes are frequently reactivated in a wide array of human cancers, where they invariably correlate with more aggressive, invasive and metastatic lesions. In the last decade, the role of TWIST proteins in canc...
متن کاملA twist of insight - the role of Twist-family bHLH factors in development.
Members of the Twist-family of bHLH proteins play a pivotal role in a number of essential developmental programs. Twist-family bHLH proteins function by dimerizing with other bHLH members and binding to cis- regulatory elements, called E-boxes. While Twist-family members may simply exhibit a preference in terms of high-affinity binding partners, a complex, multilevel cascade of regulation creat...
متن کاملNotch signaling patterns Drosophila mesodermal segments by regulating the bHLH transcription factor twist.
One of the first steps in embryonic mesodermal differentiation is allocation of cells to particular tissue fates. In Drosophila, this process of mesodermal subdivision requires regulation of the bHLH transcription factor Twist. During subdivision, Twist expression is modulated into stripes of low and high levels within each mesodermal segment. High Twist levels direct cells to the body wall mus...
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تاریخ انتشار 2015